IgG4-related sialadenitis in Uygur and Han population: clinical and pathological studies

Aims: To observe the clinical and pathological features of the IgG4-related Sialadenitis and to evaluate the clinical and pathological differences between Uygur and Han population. Materials and methods: We perform a retrospective analysis of data from Uygur patients (n=38) and Han patients (n=55) with the chronic nonspecific salivary gland inflammations which were infiltrated by multiply plasma cells. All the samples had been resected during treatment for oral lesion during 2004-2014. Formalin fixed paraffin-embedded specimens were used for immunohistochemistry, the primary antibodies were used CD38, IgG, IgG4, Kappa, Lambda. The numbers of IgG positive and IgG4 positive cells were estimated. Results: 30.91% (11 men and 6 women) Han and 26.32% (9 men and 1 woman) Uighur samples strongly suggested to be the IgG4-related sialadenitis. The main pathological findings were: diffuse lymph plasma cells infiltration through the lesion area, extensive salivary glands atrophy, The storiform-arranged type pattern resembles the spokes of a cartwheel with spindle cells radiating form a center. Even lymphoid follicle formations were commonly observed. Besides, the numbers of IgG4+ plasma cells and the IgG4+ plasma cells/IgG+ plasma cells between Han and Uygur people had significant difference in IgG4-related sialadenitis. Conclusions: IgG4-related sialadenitis is a systemic disease and may have racial variation between Uygur and Han people.